The number of coronavirus infections closed in on a half-million worldwide Thursday, with both Italy and the U.S. on track to surpass China, and a record-shattering 3.3 million Americans applied for unemployment benefits in a single week in a stark demonstration of the damage to the world's biggest economy.

Health care systems in Europe and New York buckled under the strain, with Spain's death toll climbing to more than 4,000.

In the U.S., an unprecedented $2.2 trillion economic rescue package to help businesses, hospitals and ordinary Americans make it through the crisis cleared the Senate and is expected to be voted on in the House on Friday. The plan would dispense checks of $1,200 per adult and $500 per child.